BDBM11273 2-{[5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)acetamide::CHEMBL210497::acs.jmedchem.1c00409_ST.684::pyrimidinone-containing compound 10

SMILES COc1cccc(c1)-c1nc(SCC(=O)Nc2ccc(cc2)S(N)(=O)=O)[nH]c(=O)c1C#N

InChI Key InChIKey=MFBIUOFKXQKEGQ-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 11273   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM11273(2-{[5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydrop...)
Affinity DataIC50:  4.24E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM11273(2-{[5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydrop...)
Affinity DataKd:  3.84E+4nMAssay Description:Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed